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Title   간세포암에서 p53 , p27kip1 의 발현양상과 임상병리학적 소견과의 상관관계 ( Correlation between p53 and p27kip1 Expression and Clinicopathologic Features in Hepatocellular Carcinoma )
Publicationinfo   2000 Jan; 032(02): 390-398.
Key_word   Hepatocellular carcinoma, p53, p27Kip1, Clinicopathologic features
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Abstract   Purpose: The aim of this study was to evaluate the expression of p53 and p27Kip1 and its association with numerous prognostic indicators of hepatocellular carcinoma (HCC). Materials and Methods: We reviewd the clinicopathologic features of 59 patients with HCC between 1993 and 1998. p53 and p27Kip1 expression were evaluated for relation with level of AFP, presence of HBsAg and microscopic findings such as Edmonson grade, grade of mitosis, cirrhotic background, tumor margin and Ki67 labeling index. Results: The expression rate of p53 was positively correlated with with Edmonson grade, high mitosis, infiltrative tumor margin and level of serum AFP. The expression rate of p27Kip1 was correlated inversely with Edmonson grade and presence of cirrhotic background. Ki67 labeling index was well correlated with Edmonson grade and mitotic activity. There was no correalation between p53 and p27Kip1 expression. Conclusion: The aberrant expression of p53 and p27Kip1 is well associated with various prognostic factors of HCC.
저 자   이필립(Phil Lip Lee),김주섭(Joo Seop Kim),연현철(Hyun Cheol Yeon),이영철(Young Chul Lee),이삼열(Sam Uel Lee),김덕환(Duck Whan Kim),김수태(Soo Tae Kim)